A Roadmap for Hypersensitive MCAS Patients and BodyBio PC

One of the most common questions I get is this:

“I’m so reactive. Should I even be taking BodyBio PC? Every time I try, I feel worse.”

Let’s clear this up because what you’re feeling isn’t failure. It’s feedback.

This is one of the most misunderstood moments in mitochondrial medicine. A reaction to phosphatidylcholine (PC) isn’t a sign you should stop – it’s a sign your terrain needs a little more  preparation.

First, Understand the Charge

PC isn’t just a nutrient, it’s one of the most electrically active molecules in biology. It’s rich in electrons, carries a strong negative surface potential, organizes water around your cell membranes, and helps restore the membrane potential across your cells. When you take it, you’re not just feeding your cells, you're changing their charge architecture.

This is big. It affects:

• Membrane fluidity: Determines how ions, hormones, and neurotransmitters move across the cell.

• Signaling domains: PC influences lipid rafts — the command centers of cellular communication.

• Bile flow and detox: It activates bile release, pushing out damaged lipids and stored toxins.

• Mitochondrial energy production: It restores membrane voltage, recharging the electrical field your mitochondria use to make ATP.

But here’s the catch: if your system is too inflamed, dehydrated, or in a low-voltage state, PC can feel like too much current through a frayed wire. But what you’re experiencing isn’t necessarily an allergy; it’s a sign the terrain isn’t yet ready to handle the current.

So, here’s where we start instead:

1.  Lay the Biochemical Foundation

Before we even talk about PCs, we need to talk about essential fatty acids, specifically Balance Oil.

Balance Oil is the signaling foundation for everything that comes after. The healthy omega-6 (linoleic acid) and omega-3 (alpha-linolenic acid) fats in Balance Oil regulate how your body builds phospholipids like PC. They regulate membrane synthesis, redox signaling, and the production of lipid mediators (like SPMs) that control inflammation and repair.

Without them, adding PC is like trying to wire a house before connecting it to the power grid. Too much signal. Nowhere for it to land.

So start there. Once the terrain is stable, add the PC slowly. For hypersensitive patients, I often begin with one drop topically on the skin (wrist or belly). Or for advanced cases, PC IV (under supervision) may be considered. This bypasses the gut, reduces mast cell contact, and allows for gradual systemic restoration. 

2. Support Foundational Electron Flow

Healing is electrical before it’s chemical. Every cellular function – detoxification, hormone signaling, mitochondrial repair – requires voltage. And voltage depends on one thing: electron flow.

Here’s how to rebuild that foundation:

• Hydrate with structured, mineralized water. Voltage depends on conductivity. Plain water doesn’t cut it – it needs minerals and structure to carry charge into your cells.

• Add unrefined salt to your water. Hydration is voltage, not volume. Without electrolytes, water can’t hold charge.

• Support bile flow. PC, TUDCA, bitters, lemon water, apple cider vinegar, and castor oil packs promote efficient bile release, which is key to detox and to moving stagnant energy through the system.

• Rebuild mitochondrial rhythm. Sunrise and UVA rise exposure red and near-infrared light supports mitochondrial electron flow, primes circadian signaling, and reduces oxidative stress.

Until the system holds charge, nothing lands. But once it does, everything starts to work.

3. Stabilize the Health Cycle

This is non-negotiable. Cellular medicine is fundamentally terrain-based, so before pushing repair molecules like PC, stabilize the environmental rhythms your cells evolved to trust.

• Get morning light. Spend an hour outside at sunrise to get natural light into your eyes and on your skin. Go back outside for UVA rise. This aligns cortisol, dopamine, and melatonin cycles.

• Respect the dark. Artificial light after sunset is perceived as danger, turning off repair signals and triggering oxidative stress. Use only low lamplight, red light, or candlelight at nighttime.

• Eat a local, seasonal, nutrient-rich diet. Many patients reacting to PC are also reacting to fermented foods, leftovers, and high-histamine inputs that tip the immune system into overdrive. Circadian-timed eating also supports gut motility, hormone signaling, and mitochondrial function.

• Ground to the Earth. Electron exchange from natural surfaces reduces inflammation and supports redox balance.

• Sleep in darkness. No LEDs, no Wi-Fi, just true dark. This is when mitochondrial repair happens.

• Avoid non-native EMFs. Non-native EMFs (electromagnetic frequencies) interfere with your cellular communication networks, adding noise and making it difficult for PC’s signal to land. 

Once the mitochondria have voltage, the membranes become fluid, and the circadian clock is re-aligned, you stop reacting and start rebuilding.

4. One Simple Tip

If you're still reacting, it may not be the phospholipids — it could be the ethanol.

BodyBio PC contains a very small amount of ethanol as a carrier. For highly sensitive patients, this can trigger reactions even at microdoses. Fortunately, there's an easy fix:

Pour the PC into a glass container and let it sit uncovered for a few hours. Ethanol is volatile so it naturally evaporates, leaving the phospholipids intact.

This simple step removes a small irritant for highly sensitive cells, allowing your membranes to receive the lipids without the chemical noise. It’s one of the easiest (and most overlooked) ways to improve tolerance.

Still Reacting? Here’s What to Add

If the foundation is in place and you're still reacting to PC, then we look at mast cell stabilization. MCAS (Mast Cell Activation Syndrome) often drives these reactions, especially in complex chronic illness cases. Here are some supportive measures I use:

• H1 blockers like Levocetirizine (compounded medication)

• H2 blockers like Famotidine (compounded medication)

• Cromolyn sodium taken 30 minutes before meals or PC dosing

• Quercetin + DAO enzyme for histamine metabolism and membrane stabilization

• A low-histamine diet, especially during reactive phases or hormonal transitions

These aren’t long-term drugs. They’re stabilizers, used short-term to hold the line while your body learns safety.

Don’t Give Up on PC

Phosphatidylcholine is a master molecule and one of the most potent mitochondrial and membrane repair agents in our toolkit. 

When tolerated, it’s one of the most powerful tools we have to restore mitochondrial function. If you’ve reacted to it, don’t stop completely. Slow down. Rebuild with essential fatty acids. Support the terrain.

You can’t push mitochondria against their will. They must be seduced back into coherence.

Start low and slow with BodyBio PC for cell membrane and mitochondrial repair.*