Gut+ is a prebiotic + butyrate. Butyrate is just plain butyrate. Gut+ was developed to be your all-in-one gut health solution without bacteria that you do not need. It does not smell, and uses a different form.

Animal studies suggest that you need less tributyrin than Butyrate salts hence why the dosage is lower than our Butyrate supplements. But remember, these are animal studies. Over 5000 studies have demonstrated the positive effects of all types of Butyrate. The main difference is that Gut+ does not have the distinct smell that our Butyrates does.

Both forms provide butyrate in the gut, they are simply made differently. Sodium butyrate: Produced via an acid-base reaction to form salt: NaOH+C4 H8 O2=C4 H7 COONa+H2O (Sodium Hydroxide+Butyric Acid = Sodium Butyrate+Water)

Tributyrin: Produced via esterification where 3 butyric acid is attached to a glycerol to form tributyrin: C3H8O3+3C4H8O2= C15 H26 O6+3H2O (Glycerol+Butyric Acid = Tributyrin + Water)

As three butyrate molecules bonded to one glycerol, tributyrin holds together in its journey through the digestive tract so it can reach the colon where it goes to work.

Tributyrin is the triglyceride version of butyrate/butyric acid, the short chain fatty acid (SCFA) that specific probiotics make in a balanced gut. Tributyrins are produced by esterification, an innovative technological process that removes the pungent smell of the butyrate while maintaining a high level of concentration.

The prebiotic mechanism of action in Gut+ prebiotics is a bacteriophage (phage). Phages are sub-microscopic bundles of DNA or RNA surrounded by a protein shell. Phages are abundant in the natural world, occurring in seawater, soil, humans and fermented foods. In fact, there are ten times more phages than the trillions of bacteria present in the human body. Phages exist in nature for one purpose: each to overtake a specific strain of bacteria. By using phages that target the unwanted bacteria in the gut, our probiotic phage complex is able to modulate the gut microbiota and encourage the balance of good bacteria over bad, taking full advantage of the nutrients now made available.*

Prebiotics are often fibers or starches (e.g., oligosaccharides) that have been shown to be beneficial; however, these can have some drawbacks, including:

• They require large dosages to be effective
• They can cause flatulence
• They are sensitive to the nutrients present in their specific environment
• They only work in the colon
  
  

Unlike fiber or starch-based prebiotics, PreforPro does not require large doses to be effective, and does not cause gas. It functions in both the small and large intestines, and is not affected by the competing nutrients of varying gut environments. Within hours of consumption, PreforPro goes to work on the undesirable bacteria in the gut by destabilizing the bacterial cell wall, releasing nutrients into the environment which can then be consumed by the good bacteria within the GI tract.

To supply the body with the short chain fatty acid/postbiotic butyrate.

Daily use supports a balanced gut microbiome that will allow the commensal bacteria (the bacteria that naturally fluctuates in your gut microbiome) to thrive.

Take one capsule daily, with or without food.

In human clinical studies, 300mg (3), 900mg (4), 1000mg (5), 1350mg (6), and 4,000mg (7) (8) a day have been used with safety. If your health care practitioner has prescribed more than the recommended dosage, this is at their educard discretion. 

As with our Butyrate supplement, many people use more than the recommended dose but we always recommend starting slowly with a low dose. This means you start with 1 capsule a day and you may take 1-3 gel capsules per day of Gut+ or more as directed by your HCP.

Tributyrin is affirmed as GRAS by the FDA, is regulatory compliant, and is safe for consumption

The most common symptom is changes in bowel movements or mild digestive discomfort– which are both temporary. If you're new to tributyrin, give your system a few weeks to adjust, and start out slow. There's no one size fits all solution or dosage, so make sure to listen to your body and adjust accordingly.

When first starting Gut+, your gut microbiome may need time to adjust. You may experience side effects such as minor gas, bloating or stomach rumbling, which should subside with ongoing use. Consult your healthcare professional if symptoms continue after two weeks.*

Some may feel effects within a few days of taking Gut+ and others within a few weeks. Some may not feel any effects. Just because you do not feel it, does not mean Gut+ is not working.

If your body needs a higher dose you’ll know it when you get there. This may include less digestive pains, less bloating, easier bowel movements every morning like clock work, improvements in inflammation related issues, less cravings or less desire to eat as much food, ability to tolerate more foods in diet and more…

Some studies show that beneficial effects of butyrate still get stronger even after 12 weeks of usage.

Other human studies of 1 year (12 months) of usage showed users who stayed consistent and took it regularly had higher quality of life scores compared to placebo and less digestive upset relapses. (10)

So there appears to be an additive benefit to regularly taking butyrate containing supplements week-by-week, month-by-month.

No, this supplement can be stored anywhere.

In a 2003 study of 100 patients at the U of MD who were followed for 100 days,  serum lipid parameters were measured weekly.  No changes  in TGL levels were sufficiently substantive to require discontinuation of Tributyrin.