The capsules of butyrate are vegetarian, made from plant cellulose. The butyrate powder within is enterically coated. We want to make sure that butyrate survives exposure to stomach acid and gets to the colon, where it will be most effective in supporting gut cells. Here, an approach has been devised to tackle the challenge of butyrate delivery—coating with a vegetable fat, commonly called a medium-chain triglyceride. The reasoning behind this is that a significant part of the butyrate will be released only when lipase (fat digesting enzyme) is secreted in the duodenum, the first part of the small intestine

The only difference between the two forms of BodyBio Butyrate is the minerals used to create the butyrate salt: either sodium + butyric acid, or calcium + magnesium + butyric acid. Other than that there is no difference between the two. We offer these two options because most scientific research on butyrate is conducted with sodium butyrate. This is what we recommend for most people. However, some people wish to avoid any extra sodium intake, so we created the calcium/magnesium version as an alternative. Both are equally effective.

Butyrate and Gut+ both contain butyrate in slightly different forms (butyrate vs. tributyrin). Gut+ also contains a prebiotic called PreforPro, which is a prebiotic bacteriophage designed to target unwanted bacteria in the gut. This allows your natural probiotics to flourish without taking a probiotic supplement that can cause unwanted side effects — or may simply not work at all.

With that in mind, we designed Gut+ to be your all-in-one gut health solution: prebiotics + tributyrin (butyrate) for comprehensive gut support. That said, butyrate on its own is nothing to sniff at, and we know many people rely on it for their continued gut health. A few other key differences separate Gut+ and Butyrate, so we’ve created this handy chart comparing the two.

If you are unsure which to try or are sensitive to supplements, we recommend BodyBio Butyrate (either Sodium or Calcium/Magnesium form) as a good starting point. If you find benefits from taking Butyrate regularly, you may wish to switch to Gut+ as a more advanced option in the future. If you are prescribed BodyBio Butyrate by your healthcare practitioner, follow their recommendation but feel free to share Gut+ with them as a potential treatment option.

Yes, many people take multiple doses, in the morning and evening, or even 1-2 caps with each meal. It depends on your gut and how you feel with butyrate. If you are not seeing improvement in your gut health at two caps per day, we recommend increasing your dose by one cap until you do. You may wish to split these doses throughout the day, or take them all at once — listen to your gut. When in doubt, consult your practitioner for their advice regarding dosage and timing.

You can take butyrate any time of day. Some people find that taking butyrate before bed helps them have better digestion the following morning. Some people prefer to take butyrate in the morning to set them up for the day ahead. Experiment with what works best for you

BodyBio Butyrate is simply butyrate, which is butyric acid + minerals, in our case sodium or calcium/magnesium.. Butyric acid, butyrate and tributyrin are ingredients you may see in other butyrate  supplements — same purpose, different characteristics. 

We use butyric acid aka butanoic acid, a short-chain fatty acid with four carbon atoms at its heart (found naturally in butter, hence its name). As an acid, it has a low pH so we compound it with an alkali (either sodium or calcium/magnesium), a combination that forms a salt + water. At this stage, we no longer have butyric acid, but butyrate, a buffered form of butyric acid.

This formulation is quick to break down once it reaches the gut and immediately gets to work feeding your gut cells. And it provides a sprinkling of extra minerals with either the sodium or calcium/magnesium forms. Sodium butyrate is what is used in almost all scientific studies on butyrate, but some people want to avoid extra sodium intake, so we offer the calcium/magnesium option as an alternative. Both are equally effective.

Tributyrin, which we use in Gut+, is another form of butyrate. Tributyrin is not as quickly broken down in the gut, meaning more will be absorbed into the bloodstream to be used throughout the body. If you’re looking for even more of the systemic effects of butyrate, such as metabolic, brain, and immune support, Gut+ may be a better option for you. However, both butyrate and tributyrin will have these systemic effects as well as supply fuel to the gut lining. 

We must also account for the individuality of your unique gut environment and any systemic issues present, so the body may prioritize the use of either butyrate or tributyrin wherever it sees fit

Yes, and we do not use any additives or fillers to mask the scent. Butyrate is quite infamous for its scent because it is a molecule naturally produced by the body to feed colon cells. Certain gut bacteria create butyrate via a fermentation process, so, naturally, it doesn’t smell good. Substances sometimes added to butyrate in order to control its aroma interfere with butyrate’s benefits.

No, butyrate is NOT bacteria but a short-chain fatty acid (SCFA). It’s made in the lower colon by probiotic bacteria and taken up by the colonocytes, the cells that line the colon. It then becomes an important food for those cells. A lack of good bacteria in the colon, due to antibiotic use for example, can lead to an insufficient supply of butyrate

MCT oil in Butyrate is derived from palm, palm kernel and/or coconut oil.

You can! However, it is unlikely that you get enough butyrate from your food sources to be physiologically beneficial, making butyrate supplementation a better option for gaining significant health benefits. Butyrate can also be made in the gut by consuming resistant starch, which normally comes from the skins of legumes, or underripe bananas — not foods that are commonly consumed. Learn more about butyrate in foods in this blog post.

Diets like Paleo and Keto can be deficient in fiber and resistant starch, and therefore, low in butyrate if proper dietary guidelines are not followed. When a Paleo diet is properly followed, an individual should be consuming between 9-12 cups of phytonutrient and fiber-rich plant foods including, green plantains, green bananas, sunchokes, artichokes, cooked and cooled potatoes, etc. in order to produce ample levels of butyrate. The problems arise when individuals focus exclusively on animal protein and fat while neglecting these plant foods/fibers. 

Nine cups of vegetables contain roughly 72 grams of fiber. Remember, we must also consider the health of the individual's microbiome. This factor will also influence butyrate production. 

The ability for your body to synthesize butyrate depends on several factors. Dietary fiber and resistant starch intake are critical, but we also need a plethora of probiotic bacteria in the colon to ferment the fiber that we eat and synthesize it into butyrate, acetate, and propionate (other important SCFAs). The state of the microbiome, the impact of drugs, alcohol, etc. factors into each individual's ability to produce short-chain fatty acids like butyrate. 

Chronic overeating via processed, nutrient-void foods high in energy, fat and sugar is the norm amongst the majority of North Americans. This dietary regimen creates a situation where gut health is greatly compromised and therefore, butyrate production is greatly impaired. One cannot go wrong eating a nutrient-dense diet filled with high quality animal protein and colorful, fiber-rich foods. 

It is important to note that most studies on butyrate are done via butyrate supplementation. Regardless of whether you are making adequate butyrate in the gut, we don't think you can go wrong by supporting your body with a top-up of butyrate through supplementation. Butyrate supplementation has been shown to support a healthy gut inflammation response, improve gut integrity, regulate the immune system, stabilize mood, and improve the gut/brain axis.